Ronjon Chakraverty is a Clinician Scientist and Professor of Haematology and Cellular Immunotherapy at UCL. Following his training in Internal Medicine in Cambridge, he was awarded an MRC Clinical Training Fellowship at the Institute of Molecular Medicine in Oxford where he attained his PhD in 1998. He was then appointed as transplant fellow at University College Hospital London between 1998-2000, where he was involved in the initial clinical trials of reduced intensity conditioning for allogeneic haematopoietic stem cell transplantation. In 2000, he was awarded a Senior Research Fellowship in Experimental Haematology from Leukaemia & Lymphoma Research, which funded post-doctoral studies in the laboratory of Professor Megan Sykes at Harvard. Here, his research focused upon the biology of GvL responses following adoptive cellular therapy. In 2005, he returned to UCL where he attends as a transplant physician and has attained programme-level funding for research exploring (1) the mechanisms of tissue injury in GVHD and (2) the design of strategies for increasing the engraftment and persistence of therapeutic anti-tumour T cells. Key achievements have been the demonstration of the critical role of tissue ‘licensing’ in driving GVHD and the role of non-haematopoietic cells in driving eventual exhaustion of GvL effectors.
Chakraverty R. et al. An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues. Journal of Experimental Medicine 2006 2003: 2021-2031.
Flutter B. et al. Non-hematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation. Journal of Clinical Investigation 2010, 120:3855-68
Bennett C.L. et al. Langerhans Cells Regulate Cutaneous Injury by Licensing CD8 Effector Cells Recruited to the Skin. Blood 2011 117:7063-9
D’Aveni et al. G-CSF mobilizes CD34+ regulatory monocytes that inhibit Graft-versus-Host Disease. Science Translational Medicine 2015 7: 281ra42
Veliça P et al. Genetic regulation of fate decisions in therapeutic T cells to enhance tumor protection and memory formation. Cancer Research 2015 75(13):2641-52